Their work has been exhibited at The Museum of Contemporary Art Australia, Firstdraft Gallery and the Australian Centre for Contemporary Art, among others. Through their practice, Spence explores the potential of forms and materials historically associated with abstraction and minimalism to communicate transgender experiences and histories.
Spence was supported by a Cultural Trust grant to undertake a residency at Auto Italia South East, London. During the residency, Spence visited leading curators and met with artists and researchers working across feminist, gender and political discourse to explore ideas that are integral to their artistic practice. Throughout this time, Spence developed a new body of work, including a stained-glass diptych titled Wet things dry, dry things get wet.
The residency allowed Spence to not only develop new work and gain critical recognition but to conceptualise their future practice and gain new understandings of the queer discourse and visual arts scene in the UK.